Link of a ubiquitous human coronavirus to dromedary camels.
Identifieur interne : 001176 ( Main/Exploration ); précédent : 001175; suivant : 001177Link of a ubiquitous human coronavirus to dromedary camels.
Auteurs : Victor M. Corman [Allemagne] ; Isabella Eckerle [Allemagne] ; Ziad A. Memish ; Anne M. Liljander [Kenya] ; Ronald Dijkman [Suisse] ; Hulda Jonsdottir [Suisse] ; Kisi J Z. Juma Ngeiywa [Kenya] ; Esther Kamau [Kenya] ; Mario Younan [Kenya] ; Malakita Al Masri ; Abdullah Assiri ; Ilona Gluecks [Kenya] ; Bakri E. Musa [Soudan] ; Benjamin Meyer [Allemagne] ; Marcel A. Müller [Allemagne] ; Mosaad Hilali [Égypte] ; Set Bornstein [Suède] ; Ulrich Wernery [Émirats arabes unis] ; Volker Thiel [Suisse] ; Joerg Jores [Suisse] ; Jan Felix Drexler [Allemagne] ; Christian Drosten [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Arabie saoudite (épidémiologie), Cellules Caco-2, Cellules Vero, Cellules cultivées, Chameaux (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (physiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Kenya (épidémiologie), Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
- MESH :
- génétique : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- physiologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chameaux, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infections à coronavirus, Kenya.
- Animaux, Cellules Caco-2, Cellules Vero, Cellules cultivées, Coronavirus, Humains, Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
- Wicri :
- geographic : Kenya, Arabie saoudite.
English descriptors
- KwdEn :
- Animals, Base Sequence, Caco-2 Cells, Camelus (virology), Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Coronavirus (classification), Coronavirus (genetics), Coronavirus (physiology), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Endemic Diseases, Humans, Kenya (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Phylogeny, Saudi Arabia (epidemiology), Sequence Homology, Nucleic Acid, Vero Cells.
- MESH :
- geographic , epidemiology : Kenya, Saudi Arabia.
- classification : Coronavirus.
- epidemiology : Coronavirus Infections.
- genetics : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- physiology : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- virology : Camelus, Coronavirus Infections.
- Animals, Base Sequence, Caco-2 Cells, Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Endemic Diseases, Humans, Phylogeny, Sequence Homology, Nucleic Acid, Vero Cells.
Abstract
The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.
DOI: 10.1073/pnas.1604472113
PubMed: 27528677
Affiliations:
- Allemagne, Kenya, Soudan, Suisse, Suède, Égypte, Émirats arabes unis
- Canton de Berne, District de Cologne, Rhénanie-du-Nord-Westphalie
- Berne, Bonn
- Université de Berne
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern, Switzerland;</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern</wicri:regionArea><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Jores, Joerg" sort="Jores, Joerg" uniqKey="Jores J" first="Joerg" last="Jores">Joerg Jores</name><affiliation wicri:level="4"><nlm:affiliation>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><affiliation wicri:level="1"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne</wicri:regionArea><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne</wicri:regionArea><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27528677</idno><idno type="pmid">27528677</idno><idno type="doi">10.1073/pnas.1604472113</idno><idno type="wicri:Area/PubMed/Corpus">001001</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001001</idno><idno type="wicri:Area/PubMed/Curation">001001</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001001</idno><idno type="wicri:Area/PubMed/Checkpoint">001028</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001028</idno><idno type="wicri:Area/Ncbi/Merge">001747</idno><idno type="wicri:Area/Ncbi/Curation">001747</idno><idno type="wicri:Area/Ncbi/Checkpoint">001747</idno><idno type="wicri:Area/Main/Merge">001180</idno><idno type="wicri:Area/Main/Curation">001176</idno><idno type="wicri:Area/Main/Exploration">001176</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Link of a ubiquitous human coronavirus to dromedary camels.</title><author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name><affiliation wicri:level="1"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany;</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne</wicri:regionArea><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name><affiliation wicri:level="3"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name><affiliation><nlm:affiliation>College of Medicine, Alfaisal University, 11533 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Liljander, Anne M" sort="Liljander, Anne M" uniqKey="Liljander A" first="Anne M" last="Liljander">Anne M. Liljander</name><affiliation wicri:level="1"><nlm:affiliation>International Livestock Research Institute, Nairobi, Kenya;</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>International Livestock Research Institute, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Dijkman, Ronald" sort="Dijkman, Ronald" uniqKey="Dijkman R" first="Ronald" last="Dijkman">Ronald Dijkman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern, Switzerland;</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern</wicri:regionArea><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Jonsdottir, Hulda" sort="Jonsdottir, Hulda" uniqKey="Jonsdottir H" first="Hulda" last="Jonsdottir">Hulda Jonsdottir</name><affiliation wicri:level="4"><nlm:affiliation>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern, Switzerland;</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern</wicri:regionArea><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Juma Ngeiywa, Kisi J Z" sort="Juma Ngeiywa, Kisi J Z" uniqKey="Juma Ngeiywa K" first="Kisi J Z" last="Juma Ngeiywa">Kisi J Z. Juma Ngeiywa</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Agriculture, Livestock, and Fisheries, State Department of Livestock, Department of Veterinary Services, Nairobi, Kenya;</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Ministry of Agriculture, Livestock, and Fisheries, State Department of Livestock, Department of Veterinary Services, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Kamau, Esther" sort="Kamau, Esther" uniqKey="Kamau E" first="Esther" last="Kamau">Esther Kamau</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Agriculture, Livestock, and Fisheries, State Department of Livestock, Department of Veterinary Services, Nairobi, Kenya;</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Ministry of Agriculture, Livestock, and Fisheries, State Department of Livestock, Department of Veterinary Services, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Younan, Mario" sort="Younan, Mario" uniqKey="Younan M" first="Mario" last="Younan">Mario Younan</name><affiliation wicri:level="1"><nlm:affiliation>Vétérinaires Sans Frontières Germany, Nairobi, Kenya;</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Vétérinaires Sans Frontières Germany, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Al Masri, Malakita" sort="Al Masri, Malakita" uniqKey="Al Masri M" first="Malakita" last="Al Masri">Malakita Al Masri</name><affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name><affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation><wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Gluecks, Ilona" sort="Gluecks, Ilona" uniqKey="Gluecks I" first="Ilona" last="Gluecks">Ilona Gluecks</name><affiliation wicri:level="1"><nlm:affiliation>Vétérinaires Sans Frontières Suisse, Nairobi, Kenya;</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Vétérinaires Sans Frontières Suisse, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Musa, Bakri E" sort="Musa, Bakri E" uniqKey="Musa B" first="Bakri E" last="Musa">Bakri E. Musa</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Science and Communication, Khartoum, Sudan;</nlm:affiliation><country xml:lang="fr">Soudan</country><wicri:regionArea>Ministry of Science and Communication, Khartoum</wicri:regionArea><wicri:noRegion>Khartoum</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name><affiliation wicri:level="3"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A" last="Müller">Marcel A. Müller</name><affiliation wicri:level="3"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hilali, Mosaad" sort="Hilali, Mosaad" uniqKey="Hilali M" first="Mosaad" last="Hilali">Mosaad Hilali</name><affiliation wicri:level="1"><nlm:affiliation>Cairo University, 12613 Giza, Egypt;</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Cairo University, 12613 Giza</wicri:regionArea><wicri:noRegion>12613 Giza</wicri:noRegion></affiliation></author><author><name sortKey="Bornstein, Set" sort="Bornstein, Set" uniqKey="Bornstein S" first="Set" last="Bornstein">Set Bornstein</name><affiliation wicri:level="1"><nlm:affiliation>National Veterinary Institute, 75189 Uppsala, Sweden;</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>National Veterinary Institute, 75189 Uppsala</wicri:regionArea><wicri:noRegion>75189 Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Wernery, Ulrich" sort="Wernery, Ulrich" uniqKey="Wernery U" first="Ulrich" last="Wernery">Ulrich Wernery</name><affiliation wicri:level="1"><nlm:affiliation>Central Veterinary Research Laboratory, Dubai, United Arab Emirates;</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Central Veterinary Research Laboratory, Dubai</wicri:regionArea><wicri:noRegion>Dubai</wicri:noRegion></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation wicri:level="4"><nlm:affiliation>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern, Switzerland;</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern</wicri:regionArea><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Jores, Joerg" sort="Jores, Joerg" uniqKey="Jores J" first="Joerg" last="Jores">Joerg Jores</name><affiliation wicri:level="4"><nlm:affiliation>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><affiliation wicri:level="1"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne</wicri:regionArea><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="1"><nlm:affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne</wicri:regionArea><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion><wicri:noRegion>partner site Bonn-Cologne</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Caco-2 Cells</term><term>Camelus (virology)</term><term>Cell Line</term><term>Cell Line, Tumor</term><term>Cells, Cultured</term><term>Chlorocebus aethiops</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Endemic Diseases</term><term>Humans</term><term>Kenya (epidemiology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Phylogeny</term><term>Saudi Arabia (epidemiology)</term><term>Sequence Homology, Nucleic Acid</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Arabie saoudite (épidémiologie)</term><term>Cellules Caco-2</term><term>Cellules Vero</term><term>Cellules cultivées</term><term>Chameaux (virologie)</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (physiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Kenya (épidémiologie)</term><term>Lignée cellulaire</term><term>Lignée cellulaire tumorale</term><term>Maladies endémiques</term><term>Phylogénie</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Kenya</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term><term>Kenya</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Caco-2 Cells</term><term>Cell Line</term><term>Cell Line, Tumor</term><term>Cells, Cultured</term><term>Chlorocebus aethiops</term><term>Endemic Diseases</term><term>Humans</term><term>Phylogeny</term><term>Sequence Homology, Nucleic Acid</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Caco-2</term><term>Cellules Vero</term><term>Cellules cultivées</term><term>Coronavirus</term><term>Humains</term><term>Lignée cellulaire</term><term>Lignée cellulaire tumorale</term><term>Maladies endémiques</term><term>Phylogénie</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence nucléotidique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Kenya</term><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Kenya</li><li>Soudan</li><li>Suisse</li><li>Suède</li><li>Égypte</li><li>Émirats arabes unis</li></country><region><li>Canton de Berne</li><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Berne</li><li>Bonn</li></settlement><orgName><li>Université de Berne</li></orgName></list><tree><noCountry><name sortKey="Al Masri, Malakita" sort="Al Masri, Malakita" uniqKey="Al Masri M" first="Malakita" last="Al Masri">Malakita Al Masri</name><name sortKey="Assiri, Abdullah" sort="Assiri, Abdullah" uniqKey="Assiri A" first="Abdullah" last="Assiri">Abdullah Assiri</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name></noRegion><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Eckerle, Isabella" sort="Eckerle, Isabella" uniqKey="Eckerle I" first="Isabella" last="Eckerle">Isabella Eckerle</name><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A" last="Müller">Marcel A. Müller</name></country><country name="Kenya"><noRegion><name sortKey="Liljander, Anne M" sort="Liljander, Anne M" uniqKey="Liljander A" first="Anne M" last="Liljander">Anne M. Liljander</name></noRegion><name sortKey="Gluecks, Ilona" sort="Gluecks, Ilona" uniqKey="Gluecks I" first="Ilona" last="Gluecks">Ilona Gluecks</name><name sortKey="Juma Ngeiywa, Kisi J Z" sort="Juma Ngeiywa, Kisi J Z" uniqKey="Juma Ngeiywa K" first="Kisi J Z" last="Juma Ngeiywa">Kisi J Z. Juma Ngeiywa</name><name sortKey="Kamau, Esther" sort="Kamau, Esther" uniqKey="Kamau E" first="Esther" last="Kamau">Esther Kamau</name><name sortKey="Younan, Mario" sort="Younan, Mario" uniqKey="Younan M" first="Mario" last="Younan">Mario Younan</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Dijkman, Ronald" sort="Dijkman, Ronald" uniqKey="Dijkman R" first="Ronald" last="Dijkman">Ronald Dijkman</name></region><name sortKey="Jonsdottir, Hulda" sort="Jonsdottir, Hulda" uniqKey="Jonsdottir H" first="Hulda" last="Jonsdottir">Hulda Jonsdottir</name><name sortKey="Jores, Joerg" sort="Jores, Joerg" uniqKey="Jores J" first="Joerg" last="Jores">Joerg Jores</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></country><country name="Soudan"><noRegion><name sortKey="Musa, Bakri E" sort="Musa, Bakri E" uniqKey="Musa B" first="Bakri E" last="Musa">Bakri E. Musa</name></noRegion></country><country name="Égypte"><noRegion><name sortKey="Hilali, Mosaad" sort="Hilali, Mosaad" uniqKey="Hilali M" first="Mosaad" last="Hilali">Mosaad Hilali</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Bornstein, Set" sort="Bornstein, Set" uniqKey="Bornstein S" first="Set" last="Bornstein">Set Bornstein</name></noRegion></country><country name="Émirats arabes unis"><noRegion><name sortKey="Wernery, Ulrich" sort="Wernery, Ulrich" uniqKey="Wernery U" first="Ulrich" last="Wernery">Ulrich Wernery</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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